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All biopsy/pathology specimens that are sent for diagnosis by post must be properly packaged and labelled so that both the specimen is protected, and there is no risk of infection to those handling the package during transit [1].

Containment of specimens must be triple layered and packaging used to transfer specimens must conform to UN3373, Packing Instruction P650 requirements [2].

Ensure there are 3 layers of packaging: 

  • Primary packaging: A leakproof sealed container (e.g. a plastic sample pot) wrapped in sufficient absorbent material and placed securely into the secondary packaging, so that the contents are not damaged or able to leak.  
  • Secondary packaging: A leakproof sealed container (e.g. a plastic bag or box). This should be placed into the outer packaging and secured with suitable cushioning material.  
  • Outer packaging: Must be labelled 'BIOLOGICAL SUBSTANCE, CATEGORY B' and carry the UN3373 diamond shaped symbol.
  • Either the secondary or outer packaging must be rigid.

NB: Vehicles which collect specimens from practices and clinics are often fitted with rigid boxes in which the package is placed. These boxes may be considered to constitute the rigid outer packaging. 

Ensure paperwork/documentation to accompany the specimen is placed between the secondary and outer packaging and includes:

  • Date
  • Sender (practice details) and receiver information.
  • Emergency contact details (i.e. name and telephone number of the responsible person)
  • Description of the contents

Sources of information

  1. Guidance on regulations for the transport of infectious substances 2023-24. World Health Organisation (2023)
  2. Packaging and transport requirements for patient samples – UN3373

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